|
KMID : 0371320010610030247
|
|
Journal of the Korean Surgical Society
2001 Volume.61 No. 3 p.247 ~ p.251
|
|
|
Prognosis of GLUT1 Expression in Human Breast Carcinoma
|
|
Ahn Hyung-Joon
Lee Kil-Yeon
Lee Sang-Mok
Koh Suck-Hwan
Hong Sung-Wha
Oh Soo-Myung
Kim Youn-Hwa
|
|
|
Abstract
|
|
|
Purpose: An increase of glucose uptake and glycolytic metabolism has been reported in malignant cells as compared with normal cells and tissues. We hypothesized that human erythrocyte glucose transporter-1 (GLUT1) expression is increased in breastcarcinoma andmay be correlated with long term clinical outcome.
Methods: Two hundred ninety formalin fixed, paraffin embedded sections of infiltrating ductal carcinomas of the breast were immunostained with anti-GLUT1.
Results: Among the known clinicopathological prognostic factors, GLUT1 expression was correlated positively with histological grade (p=0.000) and tumor size (p=0.003). In a multivariate analysis, lymph node i
nvolvement and GLUT1 expression were statistically significant prognostic factors. The cummulative survival rates of GLUT1 expression and LN involvement were statistically significant (p=0.0061, p=0.0009) respectively. Our results suggest that 1) GLUT1 expression is correlated with histological grade and tumor size, and 2) GLUT1 expression correlates with a poorer prognosis in patients with infiltrating ductal carcinoma of the breast.
Conclusion: The results of our study suggest that immunohistochemical staining of GLUT1 expression is strongly associated with neoplastic progression in breast carcinoma, and that GLUT1 expression has value in estimating the prognosis of patients with breast carcinoma.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|